Upgrade your preclinical trial models

With an increasing interest in developing in vitro models of disease processes, it is important that the cell lines used reflect the natural physiological status of animals or humans.

Reynolds L.M. et al., Neuroscience Letters, 2001.

Approfondimento

As drug candidates need to be screened on cultured cells for evaluating their behaviour and properties, it is of paramount importance to upgrade cell culture models.
Cultivated cells develop a membrane composition that is different from their in-vivo tissue counterparts, therefore widening the differences between experimental models and in-vivo tissue cells.
As membrane properties differ widely from real in-vivo cells, preclinical trial results are biased and they do not represent real data; these early mistakes influence the overall set of the following studies, from preclinical analyses on animals to clinical evaluation on humans, with big budget losses for companies and organisations.
Remembrane proposes the use of Refeed and Report for cell culture membrane standardisation, in order to improve experimental model consistency reproducing more accurate models which reflect in-vivo tissue cells.
Such an upgraded experimental model means more “real” data, also resulting in a better understanding of the properties of each drug candidate and in the creation of successive trials on animals and humans.

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