12

FEB

2018

Remodeling membrane order

Blog

Cell membrane fatty acids influence fundamental properties of the plasma membrane, including membrane fluidity, protein functionality, and lipid raft signalling.

 

The fatty acid composition of T cell membrane lipids has been widely reported to influence immune and inflammatory responses. Evidence suggests that dietary n-3 PUFA may target the plasma membrane of immune cells by altering plasma membrane lipid dynamics, thereby regulating the attenuation of immune cell activation and suppression of inflammation.

As lipid-based immunotherapy might be a promising new clinical strategy for the treatment of inflammatory disorders, Fan YY and coworkers conducted in vitro and in vivo experiments to examine the effects of n-3 PUFA on CD4+ T cell membrane order, mitochondrial bioenergetics and lymphoproliferation (Fan YY et al., 2018).

 

Their interesting results demonstrate that the dynamic reshaping of human CD4+ T cell plasma membrane organisation by n-3 PUFA may modulate down-stream clonal expansion.

 

Remembrane’s unique know-how in shaping membrane lipidomics of cultured cells by tailored lipid supplements is now a must-use in immunotherapy applications and can significantly help companies in the development of more effective ATMPs and of more efficient production processes.

 

Happy culturing!!!

Remembrane’s team

 

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